The Neuroengineering Laboratory @Rice

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Our Research

Forming, storing, and using memory requires the hippocampus. Problems in the hippocampal circuit can lead to memory problems (e.g., Alzheimer's, PTSD) and also more complex disorders such as depression and anxiety. We'd like to understand how the hippocampal circuit works at a systems-level in healthy brains, how it goes wrong, and what can be done to change how it functions.

We employ standard and cutting-edge techniques: simultaneously recording the activity of dozens of neurons in behaving rodents and manipulating genetically-selected populations of neurons using light ("optogenetics").

We are developing the real-time systems that will allow us to use information decoded from neural activity to manipulate the hippocampal circuit. Why is that useful? By detecting the ensemble neural activity underlying traces of individual memories in real-time, we hope to build systems that will, for example, allow us to selectively inhibit the recall or long-term storage of traumatic episodes.
 
Read more about various research projects.

Announcements

  • "Awake Hippocampal Ripples..." paper available on Science The paper "Awake Hippocampal Sharp-Wave Ripples Support Spatial Memory", by Shantanu Jadhav, Caleb Kemere, Walter German, and Loren Frank is now availble at Science! The ripple disruption system employed ...
    Posted May 3, 2012, 4:30 PM by Caleb Kemere
  • Open-EPhys site live! After presenting the Open-Ephys software and hardware at COSYNE 2012, the open-ephys website is now live. You can find it at www.open-ephys.com. Hardware designs should ...
    Posted Mar 19, 2012, 6:50 PM by Caleb Kemere
  • Open position: postdoctoral research opportunity The Rice NeuroE research group is looking for a talented individual to join the lab. The ideal applicant would have experience doing neural recordings in awake behaving animals, strong data ...
    Posted Dec 2, 2011, 11:14 AM by Caleb Kemere
  • Open position: Undergraduate lab assistants [update: full!] Are you interested in being part of the launching of a new neuroscience lab on the Rice campus in January? I am looking for folks with an interest in the ...
    Posted Dec 13, 2011, 9:08 PM by Caleb Kemere
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