The paper "Awake Hippocampal Sharp-Wave Ripples Support Spatial Memory", by Shantanu Jadhav, Caleb Kemere, Walter German, and Loren Frank is now availble at Science! The ripple disruption system employed by Jadhav in this paper (and developed by Kemere and Frank) is one of the tools being employed in further experiments here in the Rice Neuroengineering lab.
Abstract: The hippocampus is critical for spatial learning and memory. Hippocampal neurons in awake animals exhibit place field activity that encodes current location, and sharp-wave ripple (SWR) activity during which representations based on past experiences are often replayed. The relationship between these patterns of activity and the memory functions of the hippocampus is poorly understood. We interrupted awake SWRs in animals learning a spatial alternation task. We observed a specific learning and performance deficit that persisted throughout training. This deficit was associated with awake SWR activity as SWR interruption left place field activity and post-experience SWR reactivation intact. These results provide a link between awake SWRs and hippocampal memory processes, and suggest that awake replay of memory-related information during SWRs supports learning and memory-guided decision-making.
After presenting the Open-Ephys software and hardware at COSYNE 2012, the open-ephys website is now live. You can find it at www.open-ephys.com. Hardware designs should arrive any day to the website. Josh has done a great job with the software from a design and adaptability perspective.
The Rice NeuroE research group is looking for a talented individual to join the lab. The ideal applicant would have experience doing neural recordings in awake behaving animals, strong data analysis skills, and a particular interest in real-time manipulation of neural coding. Applicants with a background in signal processing algorithms and an interest in learning techniques for electrophysiology in awake behaving rodents will also potentially be considered.
Further information about the NeuroE lab can be found on this website. The position is available starting immediately, with a two year, potentially renewable, appointment. Please send applications including a CV and contact information for two references to caleb.kemere [at] rice.edu.
Are you interested in being part of the launching of a new neuroscience lab on the Rice campus in January? I am looking for folks with an interest in the neuroscience of cognition and behavior who would be interested in helping with experiments.
In the next few years, experiments in the lab will likely vary from the simple (e.g., developing new behavioral paradigms, testing the expression of new viral vectors) to the more complex (e.g., neural recording experiments, real-time feedback system hardware/software development) to the almost science fiction (e.g., selectively erasing particular memories). I would love to talk to you if you'd be interested in working in the lab during the spring semester.
Update (11/26/2011): If you're interested in being an undergrad lab assistant, please make an appointment to come meet me sometime after January 1st!
Update (12/13/2011): We're definitely at capacity for spring semester, but if you're SUPER excited and available for future semesters, come talk to me anyway!
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